|
Bilirubin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
|
31675503 |
2019 |
|
Gilbert Disease (disorder)
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Effect of UDP-glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome.
|
31017737 |
2019 |
|
Gaucher Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Production of recombinant human acid β-glucosidase with high mannose-type N-glycans in rice gnt1 mutant for potential treatment of Gaucher disease.
|
30822514 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
UGT1 and UGT2 enzymes have important roles in pharmacology and toxicology including contributing to interindividual differences in drug disposition as well as to cancer risk.
|
30724669 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
UGT1 and UGT2 enzymes have important roles in pharmacology and toxicology including contributing to interindividual differences in drug disposition as well as to cancer risk.
|
30724669 |
2019 |
|
Metabolic Syndrome X
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population.
|
30621171 |
2019 |
|
Bilirubin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population.
|
30621171 |
2019 |
|
Bilirubin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Very low-depth whole-genome sequencing in complex trait association studies.
|
30576415 |
2019 |
|
Biliary calculi
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.
|
30504769 |
2018 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Finally, we also found that the expression of GnT-I was important for cell survival, resistance to cancer drugs, and increased colony formation.
|
30307765 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Finally, we also found that the expression of GnT-I was important for cell survival, resistance to cancer drugs, and increased colony formation.
|
30307765 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Cholestasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed expression levels of UDP-glucuronosyltransferase 1-1 (UGT1A1), organic anion-transporting polypeptide 1A4 (OATP1A4), multidrug resistance-associated protein 2 (MRP2), multidrug resistance protein 1, sodium-dependent taurocholate cotransporter, and organic anion-transporting polypeptide 1A2 were significantly inhibited in cholestasis rats, which would account for reducing the drug absorption and the metabolic process of YCHD in cholestatic rats.
|
29867509 |
2018 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Currently, pharmacogenomic testing of all childhood cancer patients with an indication for doxorubicin or daunorubicin therapy for RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 variants is recommended.
|
29713898 |
2018 |
|
Colorectal Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of SNPs rs2070959 and rs1105879 in UGT1A6 gene showed interaction between aspirin use and CRC risk (Pinteraction = 0.01 and 0.02, respectively); stratification by aspirin use showed an association for decreased CRC risk for aspirin users having a wild-type genotype (rs2070959 OR = 0.77, 95% CI = 0.68-0.86; rs1105879 OR = 0.77 95% CI = 0.69-0.86) compared to variant allele cariers.
|
29425227 |
2018 |
|
Bilirubin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Individuals with genotype AA of UGT1A6 rs2070959 in the Yi group had a higher risk for HBV infection than in the Yao and Han groups.
|
29239247 |
2018 |
|
Status Epilepticus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ugt1a6 was elevated by 1.8-fold in the cortex in both SE and non-response (non-epileptic seizure response) rats, implying that Ugt1a6 induction may be independent from SE.
|
29131354 |
2018 |
|
Seizures
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
The odds ratio indicated a higher risk of early post-traumatic seizure occurrence in male patients (OR 1.96, 95% CI 1.01-3.81, p = 0.043), age over 65 (OR 2.13, 95% CI 1.01-4.48), and with UGT1A6_19T > G/541A > G/552A > C double heterozygosities (OR 2.38, 95% CI 1.11-5.10, p = 0.02), though the power of the difference was between 0.54 to 0.61.
|
28841884 |
2017 |
|
Post traumatic seizures
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
UGT1A6_19T > G/541A > G/552A > C double heterozygositie is associated with occurrence of early post-traumatic seizures in addition to patients' age and gender.
|
28841884 |
2017 |
|
Leukopenia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Associations were found between toxicities and gene variants (P<0.05), including neutropenia with ABCB1 (rs1045642) and SLC0B3 (rs4149117 and rs7311358); and diarrhoea with CYP2C9 (rs1057910), CYP2C19 (rs3758581), UGT1A6 (rs4124874) and SLC22A1 (rs72552763).
|
28817838 |
2017 |
|
Neutropenia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Associations were found between toxicities and gene variants (P<0.05), including neutropenia with ABCB1 (rs1045642) and SLC0B3 (rs4149117 and rs7311358); and diarrhoea with CYP2C9 (rs1057910), CYP2C19 (rs3758581), UGT1A6 (rs4124874) and SLC22A1 (rs72552763).
|
28817838 |
2017 |